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EU: Two EURL ECVAM recommendations for alternative methods

The European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) published a Recommendation on the Direct Peptide Reactivity Assay (DPRA) for skin sensiti­zation on December 12, 2013. The information that DPRA can provide on the sensitization potential of substances will likely be used in combination with other information sources and test methods within integrated testing strategies.


EURL ECVAM further published a Recommendation on the Cell Transformation Assay (CTA) for carcinogenicity testing us­ing the Bhas 42 cell line on December 17, 2013. After the CTA using primary hamster cells, this variant using the Bhas 42 cell line is the second CTA to achieve a Recommendation. The docu­ment concludes that the Bhas 42 CTA can provide important in­formation on the carcinogenicity potential of substances when used within integrated approaches for assessment and testing.



DPRA Recommendation:

Bhas 42 Recommendation:

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