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EU: EURL ECVAM survey and method solicitation for in vitro toxicokinetics

Toxicokinetics (TK) refers to the absorption, distribution, metabolism, and excretion (ADME) of chemical substances in the body. TK information is essential in regulatory safety assessment of chemicals. Aspects also include interspecies and route-to-route extrapolation, development of mechanistic understanding of TK processes, and better interpretation of systemic toxicity data.


Hepatic metabolic clearance plays a key role in the transformation and the elimination of chemicals from the human body and in recent times various in vitro methods for human hepatic metabolic clearance/stability have been developed. With the present survey, EURL ECVAM (the European Union Reference Laboratory for Alternatives to Animal Testing) seeks to identify in vitro human hepatic metabolic clearance/stability methods, which can contribute to the development of harmonized standards and associated international TK test guidelines.


Deadline: June 30, 2014




Posted on EU-NETVAL website

March 20, 2014

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