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EU: DB-ALM update launched

The EURL ECVAM’s DataBase service on ALternative Methods, DB-ALM, provides comprehensive and evaluated descriptions of alternative methods in use for regulatory or research purposes in biomedical sciences. Information at various levels of detail is provided, such as summary descriptions and/or more detailed information to allow the transfer and use of a method in a laboratory. Current focus is given to toxicological evaluations of chemicals.


DB-ALM 2014 is now available online, based on an entirely redesigned data retrieval approach offering more flexibility and support. This version was presented during the 9th World Congress on Alternatives and Animal Use in the Life Sciences in Prague this August, where first positive feedback was collected.


Together with the revised DB-ALM 2014, the following method descriptions have been published for in vitro methods compliant with regulatory requirements and/or undergoing validation by the EURL ECVAM in the areas of carcinogenicity, eye irritation and skin sensitization:


– Bhas 42 cell transformation assay in 6- and 96-well plates (Method Summary and Protocol No. 156)

– In vitro BALB/c 3T3 Cell Transformation Assay (BALB/c 3T3 CTA) (Method Summary and Protocol No. 137)

– Ocular Irritection® Assay System (Protocol No. 157)

– Human Cell Line Activation Test (h-CLAT) (Protocol No. 158)

DB-ALM is available at:



Adapted from

September 30, 2014

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