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Editorial
Sonja von Aulock
Food for thought
Thomas Hartung, Sebastian Hoffmann, and Martin Stephens:
Mechanistic validation
Martin Paparella, Mardas Daneshian, Romana Hornek-Gausterer, Maximilian
Kinzl, Ilse Mauritz, and Simone Mühlegger:
Uncertainty of testing methods – What do we (want to) know?
MAIN ARTICLES
Si Wang, René Houtman, Diana Melchers, Jac Aarts, Ad Peijnenburg, Rinie
van Beuningen, Ivonne Rietjens, and Toine Bovee:
A 155-plex high-throughput in vitro coregulator binding assay for
(anti-)estrogenicity testing evaluated with 23 reference compounds
Simonetta Ferruzza, Carlotta Rossi, Yula Sambuy, and Maria Laura
Scarino:
Serum-reduced and serum-free media for differentiation of Caco-2 cells
t4 report:
Nina Hasiwa, Mardas Daneshian, Peter Bruegger, Stefan Fennrich, Astrid
Hochadel, Sebastian Hoffmann, Felix E. Rivera-Mariani, Christoph Rockel,
Stefanie Schindler, Ingo Spreitzer, Sandra Stoppelkamp, Kranthi Vysyaraju, and
Thomas Hartung:
Evidence for the detection of non-endotoxin pyrogens by the whole blood
monocyte activation test
t4 workshop report:
Tzutzuy Ramirez, Mardas Daneshian, Hennicke Kamp, Frederic Y. Bois,
Malcolm R. Clench, Muireann Coen, Beth Donley, Steven M. Fischer, Drew R.
Ekman, Eric Fabian, Claude Guillou, Joachim Heuer, Helena T. Hogberg, Harald
Jungnickel, Hector C. Keun, Gerhard Krennrich, Eckart Krupp, Andreas Luch,
Fozia Noor, Erik Peter, Bjoern Riefke, Mark Seymour, Nigel Skinner, Lena
Smirnova, Elwin Verheij, Silvia Wagner, Thomas Hartung, Bennard van Ravenzwaay,
and Marcel Leist:
Metabolomics in toxicology and preclinical research
COMMENT
Marcel Leist and Thomas Hartung:
REPRINT: Inflammatory findings on species extrapolations: humans are
definitely no 70-kg mice
CONFERENCE REPORT
Costanza Rovida, Stefan F. Martin, Manon Vivier, Hans Ulrich Weltzien,
and Erwin Roggen:
Advanced tests for skin and respiratory sensitization assessment
SYMPOSIUM REPORT
Costanza Rovida, Isabella De Angelis, and Stefano Lorenzetti:
Alternative in vitro methods to characterize the role of Endocrine
Active Substances (EASs) in hormone-targeted tissues
WORKSHOP REPORT
Judith van Luijk, Marlies Leenaars, Carlijn Hooijmans, Kim Wever, Rob
de Vries, and Merel Ritskes-Hoitinga:
Towards evidence-based translational research: The pros and cons of
conducting systematic reviews of animal studies
CORNERS
ASCCT
CAATfeed
ecopa
ICCVAM/NICEATM
IIVS
NEWS
AUT: Austrian Animal Protection Law demands cost-benefit analysis
EU: Final ban on animal experiments for cosmetic ingredients implemented
EU: EPAA review on 2R methods for reproductive toxicity in industry published
GER: Grant program on alternatives to animal experiments
GER: Marcel Leist and Stephan Reichl receive Felix Wankel Animal Protection
Research Prize
GER: Call for applications for research prize on alternative methods
GER: Animal ethicist Ursula Wolf receives research prize
SUI: Egon Naef Foundation Research Prize for Luc Stoppini
UK: Chair for Animal Replacement Science announced
UK: 3Rs Prize awarded to Donald Ingber for lung-on-a-chip device
USA: Martin L. Stephens receives SoTEnhancement of Animal Welfare Award
INSTRUCTIONS FOR AUTHORS
CALENDAR OF EVENTS
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