Spec. Issue 2006 - Article Summary

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The use of in silico technologies to predict toxicity and fate: Implementation and acceptance

Mark T. D. Cronin
School of Pharmacy and Chemistry, Liverpool John Moores University, Liverpool, England
In silico technologies provide the capability to predict the toxicity and fate of chemicals without the use of animals. These approaches include the use of existing data, read-across, (quantitative) structure-activity relationships (Q)SARs and expert systems. There are a large number of implementation activities relating to the use of (Q)SARs in the forthcoming REACH legislation. Much work is being focussed on developing strategies for testing, user-friendly tools and determining how a prediction from a (Q)SAR may be evaluated for acceptance. This paper reviews these areas and identifies key areas for future research effort.

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