Spec. Issue 2006 - Article Summary

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The importance of Good Cell Culture Practice (GCCP)

Michael Balls1, Sandra Coecke2, Gerard Bowe2, John Davis3, Gerhard Gstraunthaler4,
Thomas Hartung2, Robert Hay5, Otto-Wilhelm Merten6, Anna Price2, Leonard M. Schechtman7,
Glyn Stacey8 and William Stokes9

1FRAME, Nottingham, UK; 2European Centre for the Validation of Alternative Methods (ECVAM), Ispra (VA), Italy;
3Research and Development Department, Bio-Products Laboratory, Elstree, Herts., UK; 4Department of Physiology, Innsbruck
Medical University, Innsbruck, Austria; 5ATCC, Manassas, VA, USA; 6Généthon, Evry, France; 7National Center for
Toxicological Research, Food and Drug Administration, Rockville, MD, USA; 8Division of Cell Biology and UK Stem Cell Bank,
National Institute for Biological Standards and Control, Blanche Lane, Potters Bar, Herts., UK; 9National Toxicology
Program Interagency Center for the Evaluation of Alternative Toxicological Methods Environmental Toxicology Program,
National Institute of Environmental Health Sciences, Research Triangle Park, USA

Following a suggestion made at the 3rd World Congress on Alternatives and Animal Use in the Life Sciences (1999) and the subsequent publication in 2002 of outline guidelines on Good Cell Culture Practice (GCCP), a second ECVAM Task Force was convened, with a
broader range of expertise in cell and tissue culture, in order to produce an updated and more-detailed GCCP guidance document for practical use in the laboratory. This GCCP Guidance, which has been published in ATLA in 2005 and is being made freely available, is based on six operational principles, which are briefly summarised in this paper.

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