Spec. Issue 2006 - Article Summary

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RNA interference: A novel alternative approach in nephrotoxicity studies

Eric Campbell, Craig Slattery, Niamh Tuite, Stephen Nolan, Martin Leonard, Michael P. Ryan and Tara McMorrow
Department of Pharmacology, Conway Institute, School of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
One of the main goals in functional genomics has been the development of tools that allow easy manipulation of gene expression levels that would be suitable for high throughput screening. RNA interference (RNAi) has emerged as one of the preferred approaches to achieve this goal. It is an important biological mechanism in the regulation of gene expression in animals and plants. Here we evaluated the use of RNAi for knockdown of specific gene expression as an alternative to the production of transgenic animals. RNAi development may be in the early stages, however, the real and theoretical advantages of this system in reducing the use of animals merit further investigations.

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