Spec. Issue 2006 - Article Summary

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ICCVAM progress in evaluating in vitro test methods for identifying severe ocular irritants/corrosives

Jill Merrill1, Karen Hamernik2, Leonard M. Schechtman1, William Stokes3 and Marilyn Wind4
1US Food and Drug Administration, Center for Drug Evaluation and Research, Rockville, MD, USA; 2U. S. Environmental
Protection Agency, Washington, DC, USA; 3National Toxicology Program Interagency Center for the Evaluation of Alternative
Toxicological Methods, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA;
4Consumer Product Safety Commission, Bethesda, MD, USA
The views expressed in this paper do not necessarily represent the official positions of any US Federal government agencies.

In response to a nomination by the US Environmental Protection Agency, the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) initiated a review of the validation status of four in vitro test methods for use in screening chemicals
for severe eye irritation or corrosion. The four test methods are the isolated rabbit eye test (IRE), isolated chicken eye test (ICE), hen's egg test on chorioallantoic membrane (HET-CAM) and bovine corneal opacity and permeability assay (BCOP). Background review documents (BRDs) were prepared based on the available data and independently reviewed by an Expert Panel. This paper describes the status of the review process as of August, 2005.

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