Spec. Issue 2006 - Article SummaryBack to table of contents Spec. Issue 2006
Detection of non-genotoxic carcinogens using ras-transfected Bhas 42 cells
Hatano Research Institute, Food and Drug Safety Center, Kanagawa, Japan
|The cell transformation test employing Bhas 42 cells (v-Ha-ras-transfected BALB/c 3T3 cells) was shown to be a sensitive screening method for the detection of chemicals with different mechanisms of transforming potential. Because of the simplicity of the procedure,|
it is anticipated that further investigations on Bhas assays will open ways of not only detecting non-genotoxic carcinogens but also of elucidating mechanisms of carcinogenesis.