Spec. Issue 2006 - Article Summary

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Detection of non-genotoxic carcinogens using ras-transfected Bhas 42 cells

Makoto Umeda
Hatano Research Institute, Food and Drug Safety Center, Kanagawa, Japan
The cell transformation test employing Bhas 42 cells (v-Ha-ras-transfected BALB/c 3T3 cells) was shown to be a sensitive screening method for the detection of chemicals with different mechanisms of transforming potential. Because of the simplicity of the procedure,
it is anticipated that further investigations on Bhas assays will open ways of not only detecting non-genotoxic carcinogens but also of elucidating mechanisms of carcinogenesis.

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