Spec. Issue 2006 - Article Summary

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Can toxicogenomics be used to identify chemicals that cause ocular injury?

Mike Boulton1,2 and Mike Wride2
1Department of Ophthalmology & Visual Sciences, The University of Texas Medical Branch, Galveston, Texas, USA;
2School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK

With the impending ban by the European Union on the use of the Draize eye test for cosmetic testing and to meet concerns regarding the 3Rs, an in vitro replacement is essential. This article considers a toxicogenomic approach that will allow a gene fingerprint to be produced from chemical exposure of corneal constructs prepared from human cell lines. Differential fingerprint profiles will allow identification of mild, intermediate and severe toxic preparations. This toxicogenomic approach will provide a rapid, high throughput, accurate diagnostic assay for the effects of toxic chemicals on the eye.

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