Spec. Issue 2006 - Article Summary

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A novel quantitative in vitromodel of angiogenesis

Mahtab Bahramsoltani, Sabine Käßmeyer and Johanna Plendl
Faculty of Veterinary Medicine, Institute of Veterinary Anatomy, FU Berlin, Germany
Quantification of angiogenesis, which is done particularly in animal models, is a prerequisite for the determination of the angiogenic or angiostatic effect of substances.
In the frame of this study, a new method for quantification of angiogenesis in vitro was established based on staging of angiogenesis by breaking down the angiogenic cascade into quantifiable steps. This method allows quantification of all phases of angiogenesis up to the development of lumenised, capillary-like structures in vitro. Validation of the method showed that routine and reproducible performance should be possible for different investigators with a maintainable effort of time and costs.

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