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Luminescent imaging technology as an opportunity to reduce and refine animal experiments: light at the end of the tunnel?

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Ina Hagelschuer1, Peter Hauff2, Anne Strube3, Sanna-Maria Käkönen4 and Georges von Degenfeld5
1 Animal Management, Bayer Schering Pharma AG, Wuppertal, Germany
2 Global Drug Discovery, Bayer Schering Pharma AG, Berlin, Germany
3 Global Drug Discovery, Bayer Schering Pharma AG, Berlin, Germany and Dept. of Biology, Chemistry and Pharmacy, Free University Berlin, Germany
4 Global Drug Discovery, Bayer Schering Pharma AG, Berlin, Germany and Dept. of Anatomy, Institute of Biomedicine, University of Turku, Finland
5 Common Mechanism Research, Bayer Schering Pharma AG, Wuppertal, Germany and Dept. of Experimental Cardiology, University of Witten-Herdecke, Germany

Summary

In vivo luminescent imaging technology was introduced in experimental life science research several years ago and has rapidly gained wide acceptance. By making use of this technology substantially more information can be gained from animal experiments than was previously possible. The concept of the 3Rs describes the aim to Refine, Reduce and Replace animal models in research. The goal of the present paper is to systematically investigate the impact of luminescent imaging on the 3Rs. In particular, three examples of applications are explained in detail so as to be accessible to the reader unfamiliar with the procedure. The examples are subsequently analysed for and categorised according to their concrete effect on animal welfare as defined by the 3Rs.


ALTEX 26(3), 177-185
doi: 10.14573/altex.2009.3.177

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