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Maximum Likelihood Classification Rule for Assessing Acute Toxicity

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Sabine Glaser and Hartmut Hecker
Institut für Biometrie, Medizinische Hochschule, D-Hannover
Summary

As an alternative to the Acute Toxic Class method (ATC) a simple procedure for the classification of substances into toxicity classes based on the maximum likelihood principle is proposed. The number of experimental animals needed as well as the reliability of the classification is similar to that of the ATC method. In the case of true LD50 values of 2000 mg/kg body weight and above it even is considerably better.


ALTEX 13(2), 88-94

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