ALTEX Archive - 2/13


Editorial
Sonja von Aulock


Contents

FOOD FOR THOUGHT

Thomas Hartung, Sebastian Hoffmann, and Martin Stephens
Mechanistic validation

Martin Paparella, Mardas Daneshian, Romana Hornek-Gausterer, Maximilian Kinzl, Ilse Mauritz, and Simone Mühlegger
Uncertainty of testing methods – What do we (want to) know?
 
MAIN ARTICLES

Si Wang, René Houtman, Diana Melchers, Jac Aarts, Ad Peijnenburg, Rinie van Beuningen, Ivonne Rietjens, and Toine Bovee
A 155-plex high-throughput in vitro coregulator binding assay for (anti-)estrogenicity testing evaluated with 23 reference compounds

Simonetta Ferruzza, Carlotta Rossi, Yula Sambuy, and Maria Laura Scarino
Serum-reduced and serum-free media for differentiation of Caco-2 cells

t4 report:

Nina Hasiwa, Mardas Daneshian, Peter Bruegger, Stefan Fennrich, Astrid Hochadel, Sebastian Hoffmann, Felix E. Rivera-Mariani, Christoph Rockel, Stefanie Schindler, Ingo Spreitzer, Sandra Stoppelkamp, Kranthi Vysyaraju, and Thomas Hartung
Evidence for the detection of non-endotoxin pyrogens by the whole blood monocyte activation test

t4 workshop report:

Tzutzuy Ramirez, Mardas Daneshian, Hennicke Kamp, Frederic Y. Bois, Malcolm R. Clench, Muireann Coen, Beth Donley, Steven M. Fischer, Drew R. Ekman, Eric Fabian, Claude Guillou, Joachim Heuer, Helena T. Hogberg, Harald Jungnickel, Hector C. Keun, Gerhard Krennrich, Eckart Krupp, Andreas Luch, Fozia Noor, Erik Peter, Bjoern Riefke, Mark Seymour, Nigel Skinner, Lena Smirnova, Elwin Verheij, Silvia Wagner, Thomas Hartung, Bennard van Ravenzwaay, and Marcel Leist    
Metabolomics in toxicology and preclinical research

COMMENT

Marcel Leist and Thomas Hartung
REPRINT: Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice

CONFERENCE REPORT

Costanza Rovida, Stefan F. Martin, Manon Vivier, Hans Ulrich Weltzien, and Erwin Roggen
Advanced tests for skin and respiratory sensitization assessment
 
SYMPOSIUM REPORT
Costanza Rovida, Isabella De Angelis, and Stefano Lorenzetti
Alternative in vitro methods to characterize the role of Endocrine Active Substances (EASs) in hormone-targeted tissues

WORKSHOP REPORT

Judith van Luijk, Marlies Leenaars, Carlijn Hooijmans, Kim Wever, Rob de Vries, and Merel Ritskes-Hoitinga
Towards evidence-based translational research: The pros and cons of conducting systematic reviews of animal studies

CORNERS
ASCCT
CAATfeed
ecopa
ICCVAM/NICEATM
IIVS

NEWS
AUT: Austrian Animal Protection Law demands cost-benefit analysis
EU: Final ban on animal experiments for cosmetic ingredients implemented
EU: EPAA review on 2R methods for reproductive toxicity in industry published
GER: Grant program on alternatives to animal experiments
GER: Marcel Leist and Stephan Reichl receive Felix Wankel Animal Protection Research Prize
GER: Call for applications for research prize on alternative methods
GER: Animal ethicist Ursula Wolf receives research prize
SUI: Egon Naef Foundation Research Prize for Luc Stoppini
UK: Chair for Animal Replacement Science announced
UK: 3Rs Prize awarded to Donald Ingber for lung-on-a-chip device
USA: Martin L. Stephens receives SoTEnhancement of Animal Welfare Award

INSTRUCTIONS


CALENDAR


IMPRINT


COVER




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