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Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation

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Anna K. Bal-Price1, Sandra Coecke1, Lucio Costa2, Kevin M. Crofton3, Ellen Fritsche4, Alan Goldberg5, Philippe Grandjean6, Pamela J. Lein7, Abby Li8, Roberto Lucchini9, William R. Mundy3, Stephanie Padilla3, Antonio M. Persico10,11, Andrea E. M. Seiler12, and Joachim Kreysa1
1 Validation of Alternative Methods Unit, Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra (VA), Italy;
2 Department of Environmental and Occupational Health Sciences, University of Washington,
Seattle, WA, USA;
3 Integrated Systems Toxicology Division, U.S. Environmental Protection Agency, Research Triangle
Park, NC, USA;
4 IUF: Leibniz Research Institute of Environmental Medicine, Duesseldorf and RWTH, Aachen, Germany;
5 Johns Hopkins University, Center for Alternatives to Animal Testing (CAAT), Baltimore, MD, USA,
6 Institute of Public
Health, Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark;
7 Center for Children’s Environmental Health, University of California, Davis, CA, USA;
8 Exponent Health Sciences, San Francisco, CA, USA;
9 Department of Experimental and Applied Medicine, Section of Occupational Health and Industrial Hygiene, University of Brescia, Italy;
10 University “Campus Bio-Medico”, Rome, Italy;
11 IRCCS “Fondazione Santa Lucia”, Rome, Italy;
12 Federal Institute for Risk Assessment (BfR), ZEBET – Alternative Methods to Animal Experiments, Berlin, Germany

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ALTEX 29(2), 202-215
DOI: 10.14573/altex.2012.2.202

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