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Evidence-based toxicology for the 21st century: Opportunities and challenges*

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Martin L. Stephens1, Melvin Andersen2, Richard A. Becker3, Kellyn Betts4, Kim Boekelheide5, Ed Carney6, Robert Chapin7, Dennis Devlin8, Suzanne Fitzpatrick9, John R. Fowle III10, Patricia Harlow11, Thomas Hartung1, Sebastian Hoffmann12, Michael Holsapple13, Abigail Jacobs11, Richard Judson14, Olga Naidenko15, Tim Pastoor16, Grace Patlewicz17, Andrew Rowan18, Roberta Scherer1, Rashid Shaikh19, Ted Simon20, Douglas Wolf14, and Joanne Zurlo1
1 Johns Hopkins University, Baltimore, MD, USA;
2 Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA;
3 American Chemistry Council, Washington, DC, USA;
4 Freelance science writer and editor, Takoma Park, MD, USA;
5 Brown University, Providence, RI, USA;
6 Dow Chemical, Midland, MI, USA;
7 Pfizer Global R&D, Groton, CT, USA;
8 ExxonMobil, Irving, TX, USA;
9 Food and Drug Administration, College Park, MD, USA;
10 Environmental Protection Agency, retired, Pittsboro, NC, USA;
11 Food and Drug Administration, Silver Spring, MD, USA;
12 seh consulting + services, Paderborn, Germany;
13 Battelle, Columbus, OH, USA;
14 Environmental Protection Agency, Research Triangle Park, NC, USA;
15 Environmental Working Group, Washington, DC, USA;
16 Syngenta, Greensboro, NC, USA;
17 DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE, USA;
18 Humane Society International, Gaithersburg, MD, USA;
19 Health Effects Institute, Boston, MA, USA; 20Ted Simon, LLC, Winston, GA, USA


The Evidence-based Toxicology Collaboration (EBTC) was established recently to translate evidence-basedapproaches from medicine and health care to toxicology in an organized and sustained effort. The EBTC held a workshop on “Evidence-based Toxicology for the 21st Century: Opportunities and Challenges” in Research Triangle Park, North Carolina, USA on January 24-25, 2012. The presentations largely reflected two EBTC priorities: to apply evidence-based methods to assessing the performance of emerging pathwaybased testing methods consistent with the 2007 National Research Council report on “Toxicity Testing in the 21st Century” as well as to adopt a governance structure and work processes to move that effort forward. The workshop served to clarify evidence-based approaches and to provide food for thought on substantive and administrative activities for the EBTC. Priority activities include conducting pilot studies to demonstrate the value of evidence-based approaches to toxicology, as well as conducting educational outreach on these approaches.

ALTEX 30(1), 74–104
DOI: 10.14573/altex.2013.1.074

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