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Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals

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Kevin M. Crofton1, William R. Mundy1, Pamela J. Lein2, Anna Bal-Price3, Sandra Coecke3, Andrea E. M. Seiler4, Holger Knaut3*, Leonora Buzanska5 and Alan Goldberg6
1 National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research triangle Park, NC, USA;
2 UC Davis School of Veterinary Medicine, University of California, Davis, CA, USA;
3 In-Vitro Methods Unit, European Centre for the Validation of Alternative Methods (ECVAM), Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra, Italy;
4 Center for Alternative Methods to Animal experiments – ZEBET, Federal Institute for Risk Assessment (BfR), Berlin, Germany;
5 Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland;
6 Center for Alternatives to Animal Testing, Johns Hopkins University, Baltimore, MD, USA


Developmental neurotoxicity testing (DNT) is perceived by many stakeholders to be an area in critical need of alternative methods to current animal testing protocols and guidelines. An immediate goal is to develop test methods that are capable of screening large numbers of chemicals. This document provides recommendations for developing alternative DNT approaches that will generate the type of data required for evaluating and comparing predictive capacity and efficiency across test  methods and laboratories. These recommendations were originally drafted to stimulate and focus discussions of alternative testing methods and models for DNT at the TestSmart DNT II meeting (http://caat.jhsph.edu/programs/workshops/dnt2.html) and this document reflects critical feedback from all stakeholders that participated in this meeting. The intent of this document is to serve as a catalyst for engaging the research community in the development of DNT alternatives and it is expected that these recommendations will continue to evolve with the science.

ALTEX 28(1), 9-15
DOI: 10.14573/altex.2011.1.009

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