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Pathway-based toxicity: History, current approaches, and liver fibrosis and steatosis as prototypes

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Catherine Willett1, Jessica Caverly Rae2, Katy O. Goyak3, Brigitte Landesmann4, Gary Minsavage3 and Carl Westmoreland5
1 The Humane Society of the United States, Washington, DC, USA;
2 DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE, USA;
3 ExxonMobil Biomedical Sciences, Inc., Annandale, NJ, USA;
4 Joint Research Centre, Institute for Health and Consumer Protection, European Commission, Ispra, Italy;
5 Safety & Environmental Assurance Centre, Unilever Research and Development, Sharnbrook, Bedford, UK


The Human Toxicology Project Consortium (HTPC) was created to accelerate implementation of the science and policies required to achieve a pathway-based foundation for toxicology as articulated in the 2007 National Research Council report, Toxicity Testing in the 21st Century: a Vision and a Strategy. The HTPC held a workshop, “Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology: Liver Toxicity Mode-of-Action,” in January, 2013, in Baltimore, MD, to further the science of pathway-based approaches to liver toxicity. This review was initiated as a thought-starter for this workshop and has since been updated to include insights from the workshop and other activities occurring in 2013. The report of the workshop has been published in the same issue of this journal (Willett et al., 2014).



ALTEX (31)4: 407-421


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