ALTEX Archive - 1/12 - WC8


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Contents

Co-Chairs Introduction

Plenary lectures
Daniel M. Weary
A Good Life for Laboratory Animals – How Far Must Refinement Go?

Makoto Hayashi
A Challenge to the Ultimate 3R’s – In SilicoApproach to Evaluate Chemical Safety for Humans

Martin L. Stephens
Pursuing Medawar’s Challenge for Full Replacement

Susanna Louhimies
EU Directive 2010/63/EU: “Implementing the Three Rs Through Policy”
 

Declaration of Montréal
Marlies Leenaars, Merel Ritske-Hoitinga, Gilly Griffin, and Elisabeth Ormandy
Background to the Montréal Declaration on the Synthesis of Evidence to Advance the 3Rs Principles in Science, as Adopted by the 8th World Congress on Alternatives and Animal Use in the Life Sciences, Montréal, Canada, on 25 August 2011

Declaration of Montréal
 

Theme I: Safety and Efficacy Testing of Chemicals, Pharmaceuticals and Biologicals

Session summaries for Theme I

Catherine Milne and Karl-Heinz Buchheit
EDQM’s 3R Activities in the Field of Quality Control of Vaccines

Mario Landys Chovel, Aleida Mandiarote, Ivis Ontivero, Tatiana Mahy, Lucy Herrera, Juan Francisco Núñez, Orialys Valle, and Yolexis Tamayo
Development of 3Rs Alternatives for Determining Potency and Toxicity of Vaccines in Cuba: Current Challenges and Research Projects in Progress

Richard A. Isbrucker
Alternative Safety Testing Strategies for Acellular Pertussis Vaccines

Juergen Hermanns, Christina Bache, Bjoern Becker, Bettina Loeschner, Thomas Montag, and Ingo Spreitzer
Alternatives to Animal Use for the LAL-Assay

Patricia C. Ryan, Scott A. Hammond, Song Ren, Petra Lutterbuese, Maria Amann, Michael D. Oberst, Kathy Mulgrew, Ryan Criste, Stacy Fuhrmann, Nancy Lee, Robert Gross, Meina Liang, Amy Schneider, Rakesh Dixit, Patrick A. Baeuerle, Benno Rattel, Steve Coats, Lorin Roskos, Bahija Jallal, and Laura Richman
In Vitro MABEL Approach for Nonclinical Safety Assessment of MEDI-565 (MT111)

Jan Rohde, Christian D. Demmler, Frank Mueller, Yoshihiro Nishi, Toshihiko Yanase and Christoph Giese
Development of a New Cell-Based Assay for the Determination of FSH Activity

John R. Fowle III
Use of Tox 21 Tools from Prioritization for Screening to Risk Assessment in the Context of Endocrine Disruption

Warren Casey, Patricia Ceger, Dave Allen, Judy Strickland, Jon Hamm, Mike Paris, and William Stokes
BG1Luc ER TA Test Method: Results of an International Validation Study and Proposed Performance Standards

Susanne Bremer, Paolo Castello, Elise Grignard, Anne Milcamps, Sharon Munn, Clemens Wittwehr, and Maurice Whelan
Supporting the Implementation of the EU Community Strategy on Endocrine Disrupters

Mathias Forjan, Katharina Stiglbrunner, Zbyněk Bureš, and Andreas Drauschke
Development of an Integrated Aerosol Measurement System in the i-Lung

Heike A. Behrensdorf-Nicol, Ursula Bonifas, Lena Böhl, Beate Krämer, and Karin Weisser
Methods for the Functional In Vitro Characterization of Tetanus Neurotoxin and Toxoids

Preeya Khanna, M. Catherine Mack, Vincent R. Walczak, Andrea Robillard, Matthew T. Hamilton, Jordana Composto, Katharine M. Martin, and Russel M. Walters
Human Ocular Response to Instillation of Surfactant Solutions and Water Across 10,000 Subjects

John R. Fowle III, John C. Redden, and Rodger D. Curren
Development of a Non-Animal Testing Strategy for Ocular Hazard Labeling of Some Specific EPA-Regulated Products

Ying Yang, Xingfen Yang, Jinyu Xue, Rodger Curren, Junming Huang, Xiaohua Tan, Xiaoping Xie, Xikun Xiong, et al.
A Procedure for Application of Eye Irritation Alternative Methods on Cosmetic Ingredients

Pascal Phrakonkham, Claudius Griesinger, Marlies Halder, and Raffaella Corvi
ECVAM-coordinated Prevalidation Study of Three Cell Transformation Assays for Chemical Carcinogenicity Testing

Pierre Aeby, Natalie Alépée, Takao Ashikaga, Sandrine Bessou-Touya, Eric Dufour, Frank Gerberick, Nicola Gilmour, Carsten Goebel, Petra Kern, Monique Marrec-Fairley, Silvia Martinozzi-Teissier, Gavin Maxwell, Hitoshi Sakaguchi, Julia Scheel, Andreas Schepky, Kerstin Reisinger, Magalie Tailhardat, and Petra Winkler
The Colipa Research and Method Development Program for Identifying and Characterizing Skin Sensitizers without Animal Testing

Mathieu Vinken, Karolien Buyl, Tamara Vanhaecke, and Vera Rogiers
Effects of RNA Interference-Mediated Suppression of Connexin43 Production on the Expression of Differentiation Markers in Cultures of Adult Primary Rat Hepatocytes

Jennifer Bolleyn, Joery De Kock, Hélène Mertens, Joanna Fraczek, Mathieu Vinken, Olivier Govaere, Tania Roskams, Vera Rogiers, and Tamara Vanhaecke
Liver-Specific miR-122 does Not Affect mRNA Levels of Cytochrome P450 Enzymes and Nuclear Receptors in Primary Rat Hepatocyte Cultures

Barbara Stefanska, Mathieu Vinken, and Moshe Szyf
Epigenetics in Toxicology: The Implications of Epigenetic Alterations Driven by External Exposures for Human Health

Horst Spielmann, Troy Seidle, Greet Schoeters, Vivian Kral, Monika Schäfer-Korting, Emily McIvor, and Andrew Rowan
AXLR8 Strategic Directions for Development of Alternatives in the EU

Milena Mennecozzi, Brigitte Landesmann, Georgina Alexandra Harris, Roman Liska, and Maurice Whelan
Hepatotoxicity Screening Taking a Mode-Of-Action Approach Using HepaRG Cells and HCA

Chantra Eskes, Kristie Sullivan, Marilyn Aardema, Horst Spielmann, Erin Hill, Greet Schoeters, Rodger Curren, Mathieu Vinken, and Bas Blaauboer
Comparing the Challenges in Developing and Implementing 3Rs Alternative Methods in Europe and the United States: Industrial and Academic Perspectives

Ngaire Dennison, David Anderson, and Kathy Ryder
The Role of Individuals in Progressing the Three Rs in Regulatory Testing

Elisabeth Kamphuis, Heidi Meyer, Constanze Göpfert, Heidelore Schildger, Kay-Martin Hanschmann, Beate Krämer, and Karin Duchow
Rabies Vaccines for Human Use: Potency Testing Without Mouse Challenge?

Andreas G. Schepky, Horst Wenck, and Joern Hendrik Reuter
Considerations for the Development of an Integrated Testing Strategy for Skin Sensitization

Gavin Maxwell, Maja Aleksic, Michael Davies, Julia Fentem, Michael Hughes, Cameron MacKay, Craig Moore, Vicki Summerfield, Fiona Reynolds, Carl Westmoreland, and Raniero Zazzeroni
Skin Sensitization: Modeling the Human Adverse Response


Theme II: Policy/Law on Animal Use, Public Engagement and Ethics Review

Session summaries for Theme II

Ajit Krishnaswamy
Strategies and Tools for Effective Public Participation

Barney T. Reed
Openness and Public Accountability – The Why, Who, What and How of It

Elisabeth H. Ormandy
The Importance of Involving the Public as Stakeholders when Developing Animal Welfare Policy

Alistair Currie
Freedom of Information and Animal Experiments

Francis Adelade Fakoya
Who is Concerned about Animal Care and Use in Developing Countries?

David I. Lewis
Young People’s Perceptions of the Use of Animals in Scientific and Medical Research in the United Kingdom

Maggy Jennings and Jane A. Smith
Ethical Review of Animal Experiments: Current Practice and Future Directions

Margaret A. Rose
Ethical Review of the Use of Animals in Research: A Reflection on the Journey

Andrew Knight
Weighing the Costs and Benefits of Animal Experiments

Virginia M. Williams
A New Zealand Commitment to Continuous Improvement in Animal Ethics Committee Decision-Making: Giving Operational Effect to Key Principles

Jon Richmond
Good Regulatory Practice: Directive 2010/63/EU – a Missed Opportunity?

Derek Fry
How Different Countries Control Animal Experiments Outside Recognized Establishments

Barbara Grune, Antje Doerendahl, Susanne Skolik, Andreas Luch, and Daniel Butzke
Information Retrieval on Alternative Methods to Animal Experiments – One of the Factors that Affect Implementation of the Three Rs in Research and Testing

Nicole Fenwick and Gilly Griffin
Scientists’ Views on the Three Rs: Comparison of Canadian and UK Scientists

William S. Stokes, Judy Strickland, and Warren Casey
Validation of the 21st Century Toxicology Toolbox: Challenges, Opportunities, and the Way Forward

Wade A. Rourke
Reduction of Animal Use through Validation of a Chemical Method of Detection for Paralytic Shellfish Toxins

I. Anna S. Olsson, Nuno H. Franco, Daniel M. Weary, and Peter Sandøe
The 3Rs Principle – Mind the Ethical Gap!

Hajime Kojima
The Japanese Center for the Validation of Alternative Methods (JaCVAM): Recent ICATM Contributions and Future Plans
 

Theme III: Incorporation of the Three Rs in Education and Training

Session summaries for Theme III

David Dewhurst
Is Animal-Free Teaching in the Life Sciences Better Teaching?

María Pilar Vinardell
Challenges of Using Alternatives to Animals in Laboratory Classes in Physiology: the Spanish Experience

Ramasamy Raveendran and Gitanjali Batmanabane
Alternatives to Animals in Teaching: Experience in an Indian Medical School

David I. Lewis
Educating the Next Generation of In Vivo Scientists: Meeting the Needs of Industry and Academia

Andrew Knight
The Potential of Humane Teaching Methods within Veterinary and Other Biomedical Education

Siaw-Yean Woon
A Veterinary Student’s Perspective on Educational Animal Use and the Potential for Humane Alternatives

Sofia I. Elzaabalawy, Mohamed A. Abdelbaki, Angham I. Abdelhakim, Walaa M. Alamir, Mohammed O. Elsayed, Mark M. Erian, Ahmed M. Hameda, Nick Jukes, Hany M. Mahdi, Mina A. Roshdy, Mai A. Shaheen
Alternatives Outreach and a New Student Movement for Humane Veterinary Education and Practice in Egypt

Anya Yushchenko, Olivier Berreville, Nick Wright, Liz White, and Erika Sullivan
Elimination of Live Terminal Surgeries in Canadian Veterinary Practice

Siri Martinsen and Nick Jukes
An Ethical Scoring System for the Production and Assessment of Alternatives in Education and Training

Maria L. Streber, Teresa Davila, Gabriel Solano, Lilly Esquivel, and Robert Henry
Production and Use of Plastinated Rat Models for Teaching/Learning Methods for Bleeding

David Dewhurst and Akiko Hemmi
A Survey of Animal Use and Alternatives in Higher Education in Europe

Liliana Ruiz
Alternatives to Animal Testing in Veterinary Education in Mexico

Lynette A. Hart, William A. Storm, Laura Ducceschi, Mary W. Wood, Fern Tablin, V. Michael Lane, and Melissa J. Bain
Personalized Resources on Animal Biology in U.S. Veterinary Medical Education

GwiHyang Lee, JinSoo Han, JinSuk Kim, MoonSeok Yoon, Lynette A. Hart, and ByungIn Choe
Development of a 3Rs Platform in Korea: Korea National Information Center for the 3Rs

Nick Jukes and Vadim Danko
A Collaborative Multi-language Website and Database for Alternatives in Education and Training
 

Theme IV: Animal Welfare for Refinement and High Quality Science

Session summaries for Theme IV

David J. Mellor
Affective States and the Assessment of Laboratory-Induced Animal Welfare Impacts

Emily Gay Patterson-Kane
The Sensitivity of Animals and Application of the Three Rs

Ngaio J. Beausoleil and David J. Mellor
Complementary Roles for Systematic Analytical Evaluation and Qualitative Whole Animal Profiling in Welfare Assessment for Three Rs Applications

Kathryn Bayne
Reliance on Behavior as a Metric of Animal Welfare

I. Joanna Makowska and Daniel M. Weary
Using Rat Behavior to Assess Aversion to Euthanasia Agents

David J. Mellor, Paul H. Hemsworth, John L. Barnett, and I. Ross Young
Species-Specific Approaches Aid Effective Implementation of the Three Rs in Farm Animal Research

Dorte Bratbo Sørensen, Nils Dragsted, and Peter Glerup
Positive Reinforcement Training in Large Experimental Animals

Ngaio J. Beausoleil, Penny Fisher, David J. Mellor, and Bruce Warburton
Ranking the Negative Impacts of Wildlife Control Methods May Help to Advance the Three Rs

B. Anne Croy and Zhilin Chen
Application of Radiotelemetric Recording to Studies of Mouse Models of Gestational Pathology (Review/Opinion)

Matthew C. Leach, Kristel Klaus, Amy L. Miller, Maud Scotto di Perrotolo, Susana G. Sotocinal, and Paul A. Flecknell
Are We Looking in the Right Place? – Implications for Assessing Pain

Shannon E. G. Duffus and Gilly Griffin
Can a focus on translatability in preclinical pain research benefit research animals?

Alicia Z. Karas, Larry Carbone, and Heidi L. Shafford
ATLAS: An Evidence Based Web Resource for Pain Control in Laboratory Animals
 

Theme V: Replacement and Reduction in Basic Research

Session summaries for Theme V

Brett A. Lidbury and Alice M. Richardson
A Pattern Recognition Bioinformatics Alternative System to Rodent Models in Fundamental Research

Maxime Y. Tondreau and François A. Auger
Emergence of Tissue-engineered Human Blood Vessels by Self-assembly as Vascular Models

Mitra R. Cowan
Refinement of Genetic Engineering Procedures

Joery De Kock, Mehdi Najar, Jennifer Bolleyn, Feras Al Battah, Gordana Raicevic, Olivier Govaere, Steven Branson, Smita Jagtap, John Antonydas Gaspar, Tania Roskams, Agapios Sachinidis, Laurence Lagneaux, Tamara Vanhaecke, and Vera Rogiers
Assessment of the Intrinsic Pluripotency of Mesoderm-Derived Stem Cells from Different Niches

Joery De Kock, Robim M. Rodrigues, Jennifer Bolleyn, Tamara Vanhaecke, and Vera Rogiers
Focus on Stem Cells as Sources of Human Target Cells for In Vitro Research and Testing

Sean Ekins and Antony J. Williams
The Future of Computational Models for Predicting Human Toxicities

Rosemary Broome, Armando Navarro, and George Kemble
A Model for Inter-Institutional 3Rs Cooperation – Sharing In Vivo Research Resources
 

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