Current Issue - 4/15



Sonja von Aulock



Lena Smirnova, Georgina Harris, Marcel Leist and Thomas Hartung

Cellular resilience


Mardas Daneshian, Francois Busquet, Thomas Hartung and Marcel Leist

Animal use for science in Europe



Research article

Veronika A. Ehrlich, Luca Dellafiora, Julie Mollergues, Chiara Dall’Asta, Patrick Serrant, Maricel Marin-Kuan, Elena Lo Piparo, Benoit Schilter and Pietro Cozzini

Hazard assessment through hybrid in vitro/in silico approach: the case of zearalenone


Research article

Patricia Ceger, David Allen, Ruili Huang, Menghang Xia and Warren Casey

Performance of the BG1Luc ER TA method in a qHTS format


Research article

Andrea Pathe-Neuschäfer-Rube, Frank Neuschäfer-Rube, Lara Genz and Gerhard P. Püschel

Botulinum neurotoxin dose-dependently inhibits release of neurosecretory vesicle-targeted luciferase from neuronal cells


Research article

Daniela Haase, Sylvia Otto, Bernd F. M. Romeike, Hans R. Figulla, Tudor C. Poerner Development and characterization of an ex vivo arterial long-term proliferation model for restenosis research


t4 workshop report

Mounir Bouhifd, Richard Beger, Thomas Flynn, Lining Guo, Georgina Harris, Helena Hogberg, Rima Kaddurah-Daouk, Hennicke Kamp, Andre Kleensang, Alexandra Maertens, Shelly Odwin-DaCosta, David Pamies, Donald Robertson, Lena Smirnova, Jinchun Sun, Liang Zhao and Thomas Hartung

Quality assurance of metabolomics

t4 workshop report

Sarah Gordon, Mardas Daneshian, Joke Bouwstra, Francesca Caloni, Samuel Constant, Donna E. Davies, Gudrun Dandekar, Carlos A. Guzman, Eric Fabian, Eleonore Haltner, Thomas Hartung, Nina Hasiwa, Patrick Hayden, Helena Kandarova, Sangeeta Khare, Harald F. Krug, Carsten Kneuer, Marcel Leist, Guoping Lian, Uwe Marx, Marco Metzger, Katharina Ott, Pilar Prieto, Michael S. Roberts, Erwin L. Roggen, Tewes Tralau, Claudia van den Braak, Heike Walles and Claus-Michael Lehr

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology


Sebastian Hoffmann

LLNA variability: An essential ingredient for a comprehensive assessment of non-animal skin sensitization test methods and strategies


Fawzy A. Elnady, Eldessouky Sheta, Ashour K. Khalifa and Hamdy Rizk

Training of upper respiratory endoscopy in the horse using preserved head and neck



Sarrah M’Barek, Christian Pellevoisin, Christophe Chesné, Francois Busquet and Ouajdi Souilem

First training on alternatives to animal experimentation in Tunisia


Mardas Daneshian

No alternatives? Animal experimentation and the future of research


Lucian Farcal, Francois Busquet, Sandra Coecke, Ioana Hristescu, Christophe Chesné, Christian Pellevoisin, Adriana Orasanu, Zorita Diaconeasa, Adrian Oros, Adela Pintea and Carmen Socaciu

Finding opportunities in the area of Alternative Methods to Animal Testing for Romania and inauguration of the Romanian Center for Alternative Test Methods (ROCAM)



Marie-Jeanne W. A. Schiffelers, Bas J. Blaauboer, Wieger E. Bakker and Coenraad F. M. Hendriksen

Regulatory acceptance and use of serology for inactivated veterinary rabies vaccines


CORNERS (download all Corners as pdf)







NEWS (download all News as pdf)

DK: Financial support for research into alternatives to animal experiments

EU: EU-ToxRisk to start in 2016

EU: DB-ALM provides non-guideline in vitro test methods in OECD compliant format

EU: ECHA responds to PETA’s petition to avoid animal tests

EU: EURL ECVAM Status Report 2015 published

EU: Patent on genetically modified rats and mice revoked

GER: Berlin 3Rs prize awarded for work published in ALTEX

GER: CERST to receive €200,000 per year for five years

GER: German Animal Welfare Research Award goes to DZF chair in Konstanz

GER: German center for the protection of experimental animals (Bf3R) opens

GER: Three 3R university chairs in Hesse to be filled

INT: New OECD Test Guidelines available

INT: PISC funds design of an in vitro test to assess the inhalation toxicity of nanomaterials

INT: PISC Prize for AOP development in AOP Wiki announced

NLD: Two revamped 3Rs websites launched

SUI: Swiss Federal Council proposes establishment of competence center

SUI: In memory of Irène Hagmann

TUN: Emerging interest in the 3Rs in Tunisia

TUR: Medical journal excludes animal experiments

TUR: Qualified ban on animal tests for cosmetics

UK: Design award for organs-on-chips

UK: New London network for stem cell and in vitro scientists

UK: NC3Rs launches new web resources

UK: NC3Rs designs mouse and rat grimace scale posters

UK: International 3Rs Prize announced for 2015

UKR: Four universities introduce alternatives to animal experiments in education

USA: USDA publishes 2014 Animal Use Statistics

USA: USDA issues guidance for reducing animal use for vaccine testing





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